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The question of how long has peptides been around unveils a rich and extensive history, stretching back well over a century. Far from being a recent phenomenon, peptides have been a subject of scientific inquiry and medical application for a significant period, with their journey evolving from foundational chemistry to cutting-edge therapeutics.

The scientific understanding of peptides as short chains of amino acids linked by peptide bonds, essentially "mini proteins," has its roots in the early 20th century. Pioneering work by scientists like Fischer laid the groundwork for envisioning the synthesis of complex molecules, including proteins. This era marked the beginning of intense research into the role of human signaling hormones, with insulin emerging as a classic and pivotal example of endogenous hormone therapy. The first attempts at oral insulin, for instance, date back to 1922, just a year after its discovery. By 1923, insulin was already being used to treat individuals with diabetes, demonstrating the early therapeutic potential of peptides.

The advent of insulin therapy in the 1920s is widely recognized as a significant milestone, marking the beginning of peptide therapeutics in medical practice. Researchers have been actively developing peptides as treatments for various medical conditions since 1921. This medical application of peptides as therapeutics began approximately a century ago, and their clinical relevance has only grown.

Beyond medicine, the history of peptides also touches upon other fields. While the exact origins are debated, some sources suggest that bioactive peptides have been studied for over 100 years, with early discoveries in 1902 by Bayliss and Starling hinting at their biological functions. In the realm of skincare, peptides had been floating around in the world of skincare since the 1970s, indicating a long-standing presence in cosmetic applications.

The research history of peptide saw a significant breakthrough in 1965 when scientists in China completed the synthesis of insulin, the world's first synthetic peptide. Beginning in the 1970s, research into neuropeptides gained momentum. The 1970s–1980s are often cited as a period when a true peptide revolution began, with researchers delving deeper into their functionalities.

The popularity of peptides has also seen a surge in specific communities. The bodybuilding and powerlifting communities have historically been tied to the use of various compounds, and peptides have found a niche there. While compounding has been around for a long time, it is gaining more recognition now, particularly in the current era.

For those seeking specialized research materials, companies like Phoenix Pharmaceuticals produces Research peptides for over 30 years, highlighting the sustained demand and development in this sector.

In recent years, there has been a boom in interest in using peptides, driven by advancements in science and their potential applications in areas like longevity research. While it is unclear how long people are taking peptides for these newer applications, the underlying science and historical use provide a strong foundation.

Looking at the broader timeline, peptide science evolved significantly from foundational chemistry to become one of the most important therapeutic platforms in modern medicine. The journey of peptides is a testament to scientific persistence and innovation, demonstrating that these molecules have been relevant and impactful for a very long time. The continuous research and development, with over 30 peptide drugs approved for conditions ranging from multiple myeloma and others since 2000, underscore the enduring and expanding role of peptides in science and medicine.